The MASCC/ISOO Annual Meeting is the pre-eminent multidisciplinary conference on supportive care in cancer. It covers the range of problems experienced by cancer patients as a result of the disease and its treatments. Topics address all stages of cancer from diagnosis, through treatment, rehabilitation, survivorship, palliative and end of life care. The main themes of the meeting are: COVID-19 and it’s impact on supportive care, cardio-oncology, models of supportive care, and bioethics. The meeting consists of three days of live content (24 – 26 June 2021), with each day operating on a different time zone. In addition, there are multiple on-demand sessions which will be released during the meeting dates. The on-demand sessions include parallel sessions on a range of topics, joint sessions with MASCC Affiliates and Partners, and “Meet the Expert sessions” (including writing for the journal and applying for MASCC designation as a Center of Excellence in Supportive Care).