This course aims to provide a comprehensive introduction to the principles and clinical practice of image-guided stereotactic body radiotherapy and cranial stereotactic radiosurgery. Participants will gain foundational knowledge on how to establish and validate a clinical stereotactic programme, focusing on technical, physical, and radiobiological aspects. The course seeks to promote a multidisciplinary approach, fostering collaboration among radiation oncologists, physicists, and radiation therapists. By addressing both the theoretical framework and practical application, the course equips participants with the necessary skills to start or refine their stereotactic practice.