This is a free, 33-hour online course offered in English. It consists of nine modules delivered asynchronously, allowing participants to complete the course at their own pace within a three-month access period. The course provides a comprehensive overview of cervical cancer biology and prevention through HPV-based screening. It covers the clinical management of individuals with positive screening results and examines the role of self-sampling in improving access to screening services. Special attention is given to screening approaches in populations such as immunocompromised individuals and those vaccinated against HPV. Finally, the course outlines essential considerations for the effective implementation of cervical cancer screening programmes. Its objective is to enhance knowledge and practical skills of healthcare professionals and programme managers in implementing HPV-based cervical cancer screening, managing positive cases, and effectively reaching diverse populations through innovative approaches like self-sampling. The course content was developed as part of the RISCC project (Risk-based Screening for Cervical Cancer), funded by the European Union’s Horizon 2020 programme (Grant number 847845).