The course focuses on the concept of evidence-based medicine and describes the methodology underlying clinical research. Areas of biomedical statistics necessary for participants to develop skills of critical reading and presentation of research evidence will be covered The course will explore the state-of-the-art of radiation therapy in the major tumour sites: breast, oesophagus and stomach, rectum, prostate, head and neck, lung, CNS and gynaecological malignancies. A separate session will deal with the major issues in palliative radiation therapy