After three highly successful editions, CHILI – the Conference on Hybrid Imaging Live – returns with its engaging online-only conference format. On October 29, from 08:30-18:00 (CET), four sessions each consisting of 4 lectures and round table discussions will be broadcast live from a professional studio in Vienna to the world. At the end of each session, there will be time for the audience to engage with the experts from the respective sessions and ask questions via an online tool. The four sessions of CHILI will cover various aspects relating to the fusion of radiology and nuclear medicine. The focus of the first session will be put on hybrid imaging as the standard of care in oncology, discussing its application for melanoma, lymphoma, carcinoma as well as HNSCC. Subsequently, the second session will explore clinical applications and therapeutic management in oncology beyond FDG, such as PSMA, FAPI, FET and SSR-targeting tracers. After a short break and a session by our industry partner, the third session will present means how to guide clinical therapy in inflammation and infection and will present the experience gained from the use of hybrid imaging in Covid-19. After another exciting presentation by one of our industry partners, the conference will conclude with a session dedicated to new developments that are on the horizon for hybrid imaging, such as total body PET/CT, novel molecular imaging probes and a lecture on how to evolve clinical applications for artificial intelligence in hybrid imaging.